The present investigation was mainly focused on the development of controlled release pellets of verapamil HCl with ethyl cellulose and hydroxylpropyl methyl cellulose phthalate by employing fluid bed coating technique. Ethyl cellulose 7cps a high viscosity grade controlled release polymer was mainly used as coating agent for regulating the drug release from pellets. HPMCP, an enteric coating polymer was used in the present study to regulate the drug release at varied G.I pH conditions. An attempt was made to optimize the composition of these two polymers to achieve the controlled release of drugs from the pellets. HPMC E5 was used a film former in the present investigation. Croscaremellose sodium was used as disintegrant to create channels in the coating for drug release. Povidone was used as binder to achieve uniform drug layering in the present investigation. The drug release rate decreased as the concentration of ethyl cellulose polymer increased. It was observed that increase in the concentration of polymers ethyl cellulose and resulted in delay in the drug release. The increase in the HPMCP polymeric concentration in formulations showed initial delay in drug release.
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